Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants

Identification of copy number variants associated with renal agenesis using array-based comparative genomic hybridization

ii ACKNOWLEDGMENTS I would like to thank all members in Dr. Manak's lab, especially to Steven Butcher, Xiaojing Hong and Riley Boland who help me for numerous times in my experiments. Also, thanks to Dr. Brophy and Jason Clarke who provide patients' DNA samples and useful information for my projects. Thanks to Song Yi and Nidhi Sahni for their nice help in thesis preparation and writing. Thanks...

MSX2 copy number increase and craniosynostosis: copy number variation detected by array comparative genomic hybridization

Karla de Oliveira Pelegrino, Sofia Sugayama, Karina Lezirovitz, Ana Lúcia Catelani, Fernando Kok, Maria de Lourdes Chauffaille I Instituto de Pesquisa e Desenvolvimento, Grupo Fleury, São Paulo/SP, Brazil. II Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo, Departamento de Pediatria, São Paulo/SP, Brazil. III Hospital das Clı́nicas da Faculdade de Medicina da Universi...

BAC to the future! or oligonucleotides: a perspective for micro array comparative genomic hybridization (array CGH)

The array CGH technique (Array Comparative Genome Hybridization) has been developed to detect chromosomal copy number changes on a genome-wide and/or high-resolution scale. It is used in human genetics and oncology, with great promise for clinical application. Until recently primarily PCR amplified bacterial artificial chromosomes (BACs) or cDNAs have been spotted as elements on the array. The ...

Statistical methods for detecting genomic alterations through array-based comparative genomic hybridization (CGH).

Array-based comparative genomic hybridization (ABCGH) is an emerging high-resolution and high-throughput molecular genetic technique that allows genome-wide screening for chromosome alterations associated with tumorigenesis. Like the cDNA microarrays, ABCGH uses two differentially labeled test and reference DNAs which are cohybridized to cloned genomic fragments immobilized on glass slides. The...

Comparative Genomic Hybridization (CGH)